Class 6: Toxic and infectious substances

Classification of hazardous goods

Class 6.1: Toxic substances

Poisons, toxic substances

Class 6.1: Toxic substancesThey have been known to provide a hazard to health during transportation or are presumed to be toxic to humans because they are in the category of toxic substances that have been tested on laboratory animals.

Also irritating materials, such as tear gas, which causes extreme irritation, especially in a confined space.

Class 6.2: Infectious substances

Infectious materials contain or are suspected in the content of pathogenic microorganisms.

3.6.2.1 Definitions for purposes of this instruction:

3.6.2.1.1 Infectious substances - substances that are known or expected to contain pathogens. Pathogens are defined as microorganisms (including bacteria, viruses, rickettsiae, parasites, fungi) and other agents such as prions, which can cause disease in humans or animals.

Marked: Factory toxins, animal or bacterial sources which do not contain infectious substances or toxins that are not contained in substances which are infectious substances, but they should be considered for classification in Division 6.1 and assigned to UN3172. 3.6.2.1.2 Biological products - are products derived from living organisms, which are produced and distributed in accordance with the relevant government authorities that may have special licensing requirements and are used by or for the prevention, treatment, or diagnosis of disease in humans or animals, or for the development, experimental or investigational purposes related thereto. These include, but are not limited to finished or unfinished products such as vaccines.

3.6.2.1.3 Cultures - the result of the process, when pathogens are produced intentionally. This definition does not include a prototype, as defined in 3.6.2.1.4.

3.6.2.1.4 prototype - collected directly from humans or animals, including isolation, secreta, blood and its components, tissue and tissue fluid swabs, and body parts being transported for purposes such as research, diagnosis, investigational activities, treatment disease and prevention.

3.6.2.1.5 Medical or clinical tests - tests resulting from the treatment of animals or humans or from bio-research.

3.6.2.2 Classification of Infectious Substances

3.6.2.2.1 Infectious substances must be classified in Division 6.2 and assigned to UN2814, UN2900, UN 3291 or UN3373, as appropriate.

3.6.2.2.2 Infectious substances are divided into the following categories.

3.6.2.2.2.1 Category A: An infectious substance which is transported in a form and transforming it, touching or interacting with him, is capable of causing permanent disability, life-threatening or fatal disease in otherwise healthy humans or animals. Illustrative examples of substances that meet these criteria are given in class 3.6. D

Note: The interaction occurs when an infected substance depressurized from the protective packaging, resulting in physical contact with humans or animals.

(A) Infectious substances meeting these criteria which cause disease in humans or in humans and animals must be assigned to UN 2814. Infectious substances which cause disease only in animals must be assigned to UN 2900.

(B) Assignment to UN 2814 or UN 2900 must be based on the known medical history and symptoms of individuals, human or animal, local to local conditions, or professional judgments about the individual circumstances of the individual human or animal.

Notes:
1. Adopted by the shipping name for UN 2814 is INFECTIOUS SUBSTANCE, infect humans. Adopted by the shipping name for UN 2900 is INFECTIOUS SUBSTANCE, infect only animals.

2. The next category is not exhaustive and definitive. Infectious substances, including new or emerging pathogens, which do not appear in the category, but which correspond to the same criteria should be assigned to Category A. In addition, if there is any doubt about whether a substance is the criteria that should be included in Category A.

3. The following list contains the microorganisms that are written in italics, and are bacteria, mycoplasmas, rickettsia or fungi.

  • Bacillus anthracis (cultures only)
  • Infectious substance
  • Brucella abortus (cultures only)
  • Brucella melitensis (cultures only)
  • Brucella suis (cultures only)
  • Burkholderia mallei – Pseudomonas mallei – Glanders (cultures only)
  • Burkholderia pseudomallei – Pseudomonas pseudomallei (cultures only)
  • Chlamydia psittaci – avian strains (cultures only)
  • Clostridium botulinum (cultures only)
  • Coccidioides immitis (cultures only)
  • Coxiella burnetii (cultures only)
  • Crimean-Congo hemorrhagic fever virus
  • Dengue virus (cultures only)
  • Eastern equine encephalitis virus (cultures only)
  • Escherichia coli, verotoxigenic (cultures only)
  • Ebola virus
  • Flexal virus
  • Francisella tularensis (cultures only)
  • Guanarito virus
  • Hantaan virus
  • Hantavirus causing hemorragic fever with renal syndrome
  • Hendra virus
  • Hepatitis B virus (cultures only)
  • Herpes B virus (cultures only)
  • Human immunodeficiency virus (cultures only)
  • Highly pathogenic avian influenza virus (cultures only)
  • Japanese Encephalitis virus (cultures only)
  • Junin virus
  • Kyasanur Forest disease virus
  • Lassa virus
  • Machupo virus
  • Marburg virus
  • Monkeypox virus
  • Mycobacterium tuberculosis (cultures only)
  • Nipah virus
  • Omsk hemorrhagic fever virus
  • Poliovirus (cultures only)
  • Rabies virus
  • Rickettsia prowazekii (cultures only)
  • Rickettsia rickettsii (cultures only)
  • Rift Valley fever virus
  • Russian spring-summer encephalitis virus (cultures only)
  • Sabia virus
  • Shigella dysenteriae type 1 (cultures only)
  • Tick-borne encephalitis virus (cultures only)
  • Variola virus
  • Venezuelan equine encephalitis virus
  • West Nile virus (cultures only)
  • Yellow fever virus (cultures only)
  • Yersinia pestis (cultures only)
  • African swine fever virus (cultures only)
  • Avian paramyxovirus Type 1 – Velogenic Newcastle disease virus (cultures only)
  • Classical swine fever virus (cultures only)
  • Foot and mouth disease virus (cultures only)
  • Goatpox virus (cultures only)
  • Lumpy skin disease virus (cultures only)
  • Mycoplasma mycoides – Contagious bovine pleuropneumonia(cultures only)
  • Peste des petits ruminants virus (cultures only)
  • Rinderpest virus (cultures only)
  • Sheep-pox virus (cultures only)
  • Swine vesicular disease virus (cultures only)
  • Vesicular stomatitis virus (cultures only)

3.6.2.2.2.2 Category B:
Infectious substance which does not meet the criteria for inclusion in Category A. Infectious substances in Category B must be assigned to UN 3373. Note: The proper shipping name of UN 3373 is Diagnostic specimens or Clinical specimens or Biological substance, category B.

3.6.2.2.3 Benefits
3.6.2.2.3.1 Substances which do not contain infectious substances or substances which are unlikely to cause disease in humans or animals that do not adhere to this instruction, if they do not meet the criteria for inclusion in another class.

3.6.2.2.3.2 Substances containing microorganisms which are non-pathogenic to humans or animals, do not adhere to this instruction, if they do not meet the criteria for inclusion in another class.

3.6.2.2.3.3 Substances in a form in which any existing pathogens have been neutralized or inactivated so that they no longer pose a health risk, do not adhere to this instruction, if they do not meet the criteria for inclusion in another class.

3.6.2.2.3.4 Environmental samples (including food and water samples), which are not believed to pose a significant threat of infection, do not adhere to this instruction, if they do not meet the criteria for inclusion in another class.

3.6.2.2.3.5 Dried blood spots, collected by applying the drop of blood on the absorbent material, or fecal occult blood screening tests and blood components or blood that was collected for transfusion or for the preparation of blood products to be used for transfusion or transplantation and any tissues or organs intended for use in transplants, do not adhere to this instruction.

3.6.2.2.3.6 Patient specimens for which there is minimal likelihood that pathogens are present, do not adhere to this instruction, if the sample is packaged in a casing that will prevent any leakage and which is marked with the words "Exempt human specimen" or "Exempt animal specimen . Packaging must meet the following conditions:

(a) The package shall consist of three components:
(i) watertight primary receptacle (s);
(ii) sealed secondary packaging, and
(iii) outer packaging of adequate strength to test its capacity, mass and intended use, and at least one surface having a minimum dimension of 100 mm × 100 mm;

(b) For liquids, absorbent material in sufficient quantity to absorb all of the content should be placed between the primary receptacle (s) and the secondary packaging so that during the transport of any release or leak of liquid substance does not reach the outer packaging and not jeopardize the integrity of the material;

(c) When a multi-purpose fragile primary receptacles are placed in a single secondary packaging, they must be either individually wrapped or separated to prevent contact between them...

Note: In determining whether a prototype has a slight likelihood that pathogens are present, an element of the professional judgments required to determine whether the substance is exempt under this paragraph. That proposition must be based on the known medical history, symptoms and individual circumstances of the source, human or animal, and local conditions.

Examples of instances that can be transported under this paragraph include the blood or urine tests for cholesterol level monitoring, blood glucose levels, hormone levels, or prostate specific antigen (PSA); required to monitor organ function such as heart, liver or kidney function for humans or animals with communicable diseases, or therapeutic drug monitoring, conducted for insurance or employment purposes and are intended to determine the presence of drugs or alcohol, pregnancy test, a biopsy to detect cancer, and detection of antibodies in humans or animals.

3.6.2.3 Biological Products
3.6.2.3.1 For the of these instructions, biological products are divided into the following groups:

(a) those which are manufactured and packaged in accordance with the requirements of relevant government authorities and transported for final packaging or distribution, and use for personal health care by medical professionals or people. Substances in this group do not adhere to this instruction.

(b) those that do not fall under paragraph (a) and knowingly or reasonably are believed to contain infectious substances and meet criteria for inclusion in Category A or B. Category sub category in this group , assign to UN2814, UN2900or UN3373 As appropriate.

Note: Some licensed biological products may present a biological hazard only in certain parts of the world. In this case, the competent authorities may require for these biological products to be in compliance with local requirements for infectious substances or may impose other restrictions.

3.6.2.4 Genetically modified microorganisms and organisms

3.6.2.4.1 Genetically modified micro-organisms not meeting a definition of infectious substance shall be classified according to class 3.9.

3.6.2.5 Medical or clinical drugs

3.6.2.5.1 Medical or clinical drugs containing category infectious substances must be assigned to UN2814 or UN2900, as appropriate. Medical or clinical materials containing infectious substances in Category B, must be assigned to UN3291

3.6.2.5.2 Medical or clinical materials that are believed to have a low probability of detention for infectious substances must be assigned to UN3291.

3.6.2.5.3 Deactivated medical or clinical drugs, which previously contained infectious substances that do not adhere to this instruction, if they do not meet the criteria for inclusion in another class.

3.6.2.6 Infected animals

3.6.2.6.1 Live animal that has been intentionally infected and contain an infectious substance shall be transported by air, if the infection contained the substance can not be sent by any other means. Infected animals may only be transported in accordance with the terms and conditions approved by the appropriate state authority.

3.6.2.6.2 If the infectious substance can not be sent by any other means, live animals should not be used to send such a substance.

3.6.2.6.3 Enclosures animals affected by pathogens of category A or which would be assigned to a category in cultures only, must be assigned to UN 2814 or UN 2900 as appropriate. Other animal carcasses affected by pathogens included in Category B, must be transported in accordance with conditions determined by the competent authority.

3.6.2.7 Prototype must be assigned to UN 2814, UN 2900 or UN 3373 as appropriate, if they perform 3.6.2.2.3

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